Publications 1984-2004

1. Brown G.L., Cobb J.P., Brown C.M., Polk H.C.: Staphylococcal lysate fails to elicit nonspecific immune enhancement in a simulated surgical infection. American Journal of Surgery, 50:663-665, 1984.

2. Drewinko B., Surgeon J., Cobb P., Callahan L., Schmidt D., Bollinger P., Trujillo J.: Comparative sensitivity of different methods to detect and quantify circulating fibrinogen/fibrin split products. American Journal of Clinical Pathology, 84:58-66, 1985.

3. Cobb J.P., Brown C.M., Brown G.L., Polk H.C.: Muramyl-dipeptide (MDP) protects decomplemented mice from surgically-induced infection. International Journal of Immunopharmacology, 8:799-803, 1986.

4. Drewinko B., Cobb J.P., Guinee V., Giacco G., Trujillo J., vonEschenbach A.: Untreated prostatic carcinoma is not associated with frequent thrombo hemorrhagic disorders. Urology, 30:11-17, 1987.

5. Cobb J.P., Goldstone J.A.: Aortocaval fistula. Perspectives in Vascular Surgery, 2:97-100, 1989.

6. Cobb J.P., Schecter W.P., Russell T.: Giant malignant tumors of the anus. A strategy for management. Diseases of the Colon & Rectum, 33:135-138, 1990.

7. Cobb J.P., Natanson C., Hoffman W.D., Lodato R.F., Banks S., Koev C.A., Solomon M.A., Elin R.J., Hosseini J.M., Danner R.L.: N-omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. Journal of Experimental Medicine, 176:1175-1182, 1992.

8. Cobb J.P., Cunnion R.E., Danner R.L.: Nitric oxide as a target for therapy in septic shock [editorial]. Critical Care Medicine, 21:1261-1263, 1993.

9. Solomon M.A., Correa R., Alexander R.H., Balban R.S., Koev C.A., Cobb J.P., Kim D.K., Roberts W.C., Cunnion R.C., Hoffman W.D., Danner R.L., Ferrans V.F., Bacher J., Yatsiv I., Banks S.M.,Natanson C.: Myocardial energy metabolism and morphology in a canine model of human sepsis. American Journal of Physiology, 266:H757-H768, 1994.

10. Van Dervort A.L., Yan L., Madera P.J., Cobb J.P., Wesley R.A., Corriveau C.C., Tropea M.M., Danner R.L.: Nitric oxide regulates endotoxin-induced TNF-alpha production in human neutrophils. Journal of Immunology, 152:4102-4109, 1994.

11. Cobb J.P., Natanson C., Quezado Z.M., Hoffman W.D., Koev C.A., Banks S., Correa R., Elin R.J., Hosseini J.M., Danner R.L.: Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs. American Journal of Physiology, 268:H1634-H1642, 1995.

12. Cobb J.P., Hotchkiss R.S., Karl I.E., Buchman T.G.: Mechanisms of cell injury and death. British Journal of Anesthesia, 77(1):3-10, 1996.

13. Cobb J.P., Danner R.L.: Nitric oxide and septic shock. JAMA, 275:1192-1196, 1996.

14. Hotchkiss R.S., Swanson P.E., Cobb J.P., Jacobson A., Buchman T.G., Karl I.E.: Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T & B cell deficient mice. Critical Care Medicine, 25:1298-1307, 1997.

15. Jacob A.K., Hotchkiss R.S., DeMeester S.L., Swanson P.E., Hiramatsu M., Karl I.E., Cobb J.P., Buchman T.G.: Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism. Surgery, 122:243-253, 1997.

16. DeMeester S.L., Buchman T.G., Qiu Y., Jacob A.K., Dunnigan K., Hotchkiss R.S., Karl I.E., Cobb J.P.: Heat shock induces I kappa B-alpha and prevents stress-induced endothelial cell apoptosis. Archives of Surgery, 132:1283-88, 1997.

17. Quezado M.N., Karzai W., Danner R.L., Freeman B.D., Yan L., Eichacker P.Q., Banks, S.M., Cobb J.P., Cunnion R.E., Quezado J.N., Sevransky J.E., and Natanson C. Effects of L-NMMA and fluid loading on TNF-induced cardiovascular dysfunction in dogs. American Journal of Respiratory and Critical Care Medicine, 157:1397-1405, 1998.

18. DeMeester SL, Cobb JP, Hotchkiss RS, Osborne DF, Karl IE, and Buchman TG. Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis. Surgery 124:362-371, 1998.

19.  DeMeester SL, Buchman TG, Qiu Y, Dunnigan K, Hotchkiss RS, Karl I, and Cobb JP. Pyrollidine dithiocarbamate activates the heat shock response and thereby induces apoptosis in primed endothelial cells. Shock 10:1-6, 1998.

20.  DeMeester SL, Qiu Y, Buchman TG, Hotchkiss RS, Dunnigan K, Karl IE, and Cobb JP: Nitric oxide inhibits stress-induced endothelial cell apoptosis. Critical Care Medicine 26:1500-9, 1998.

21. Freeman BD, Cobb JP.  Nitric oxide synthase as a therapeutic target in sepsis: More questions than answers? [Editorial]. Critical Care Medicine 26:1469-70, 1998.

22.  Cobb JP. Use of Nitric Oxide Synthase Inhibitors to Treat Septic Shock: The Light Has Changed from Yellow to Red. [Editorial] Critical Care Medicine 27:855-6, 1999.

23.  Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, BuchmanTG, Korsmeyer SJ, and Karl IE. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. Journal of Immunolology 162:4148-56, 1999.

24.  Cobb JP, Hotchkiss RS, Swanson PE, Chang K, Qiu Y, Laubach VE, Karl IE, Buchman TG.  Inducible nitric oxide synthase (iNOS) deficiency increases the mortality of sepsis in mice.  Surgery 126:438-442, 1999.

25.  Cobb JP, Qiu Y, Buchman TG. Is HSP-72 Responsible for Nitric Oxide's Ability to Block Stress-Induced Apoptosis? Critical Care Medicine, 27:1695, 1999.

26.  Hotchkiss RS, Swanson PE, Freeman BD, Tinsely KW, Cobb JP, Matuschak GM, Buchman TG, and Karl IE.  Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Critical Care Medicine 27:1230-51, 1999.

27.  Hotchkiss RS, Tinsely KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, Korsmeyer SJ, and Karl IE. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proceedings of the National Academy of Sciences, U.S.A. 96:14541-6, 1999.

28.  Cobb JP, Buchman TG, Karl IE, Hotchkiss RS.  Molecular biology of MODS:  injury, adaptation, and apoptosis.  Surgical Infections 1:207-215, 2000.

29.  Hotchkiss RS, Schmieg RE, Swanson PE, Freeman BD, Tinsely KW, Cobb JP, Karl IE, Buchman TG. Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock. Critical Care Medicine 28:3207-17, 2000.

30.  Rajan GR, Cobb JP, and Reiss CK. Acyclovir induced coma in the intensive care unit. Anaesth.Intensive Care 28:305-307, 2000.

31.  Boyle WA, Parvathaneni LS, Sauter C, Laubach VE, and Cobb JP. iNOS gene expression modulates microvascular responsiveness in endotoxin-challenged mice. Circulation Research,  87: e18 - e24, 2000.

32.  DeMeester SL, Buchman TG, and Cobb JP. The heat shock paradox: Does NF-kB determine cell fate? FASEB Journal, 15:270-274, 2001.

33.  Freeman BD, Isabella K, Cobb JP, Boyle WA, Schmieg RE, Kollef MH, Lin C, Saak T, Thompson EC, and Buchman TG. A prospective randomized study comparing percutaneous and surgical tracheosotmy in critically ill patients. Critical Care Medicine 29:926-930, 2001.

34.  Cobb JP, Brownstein BH, Watson MA, Shannon WD, Laramie JM, Qiu Y, Stormo GD, Morrissey JJ, Buchman TG, Karl IE, and Hotchkiss RS. Injury in the Era of Genomics. Shock 15:165-170, 2001.

35.  Hotchkiss RS, Tinsely KW, Swanson PE, Schmieg RE, Hui JJ, Chang KC, Osborne DF, Freeman BD, Cobb JP, Buchman TG, and Karl IE. Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4⁺ T Lymphocytes in Humans. Journal of Immunology 166: 6952-6963, 2001.

36. Buchman TG, Lapedes AS, Cobb JP, and Kepler TB. Complex Systems Analysis: A tool for Shock Research. Shock 16: 248-251, 2001.

37. Cobb JP and Buchman TG. microArRAYs OF HOPE. Shock 16: 264-265, 2001.

38. Cobb JP. Nitric oxide synthase inhibition as therapy for sepsis: A decade of promise. Surgical Infections 2: 93-101, 2001.

39. Chung TP, Laramie JM, Cobb JP.  Functional Genomics of Critical Illness and Injury. Critical Care Medicine 30 (1 Supp) :S51-S57, 2002.

40. Hotchkiss RS, Tinsely KW, Swanson PE, Grayson MH, Wagner TH, Cobb JP, Coopersmith C, and Karl IE. Depletion of dendritic cells but not macrophages in patients with sepsis. Journal of Immunology 168: 2493-500, 2002.

41. Cobb JP, Laramie JM, Morrissey JJ, Shannon WD, Qiu Y, Karl IE, Buchman TG, and Hotchkiss RS. Sepsis Gene Expression Profiling: Murine Splenic Compared to Hepatic Responses Determined Using cDNA Microarrays. Critical Care Medicine 30: 2711-2721, 2002.

42. Dasu MRK, Cobb JP, Laramie JM, Chung TP, Spies M, and Barrow RE. Gene Expression Profiles of Livers from Thermally Injured Rats. Gene 327:51-60, 2004.

43. Wizorek JJ, Coopersmith CM, Laramie JM, Tong A, Stromberg PE, Hotchkiss RS, Buchman TG, Cobb JP. Sequence Makes a Difference: Paradoxical Effects of Stress in vivo. Shock 22:229-233, 2004.

44. Cobb JP and O'Keefe GE. Injury Research in the Genomic Era. Lancet 363:2076-2083, 2004.

45. Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A,  MacMillan SK, Laramie JM, Xiao W, Moldawer LL, Cobb JP, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG. Whole Blood and Leukocyte RNA Isolation for Gene Expression Analyses. Physiological Genomics 19: 247-254, 2004.