CURRICULUM VITAE

J. Perren Cobb, M.D.

Contact:

J. Perren Cobb, M.D., F.A.C.S.

Professor

Departments of Surgery and Genetics

Campus Box 8109

660 South Euclid Avenue

St. Louis, MO 63110

phone (314) 362-1264

fax (314) 362-7474

cobb@wustl.edu

www.cia.wustl.edu

Education and Training:

• 1982 Bachelor of Arts, magna cum laude, Vanderbilt University, Nashville, TN
• 1986 Medicinae Doctor, cum laude, University of Louisville School of Medicine, Louisville, KY
• 1986 - 1994 Resident, Division of General Surgery, Department of Surgery, University of California-San Francisco, CA
• 1989 - 1992 Fellow, Critical Care Medicine Department., National Institutes of Health, Bethesda, MD
• 1994 - 1995 Fellow, Multidisciplinary Critical Care Training Program, University of Pittsburgh, PA

Board Certification:

• National Board of Medical Examiners, 1987
• American Board of Surgery, 1996 (recertified, 2006)
• Added Qualifications in Surgical Critical Care, American Board of Surgery, 1997 (recertified, 2007)

Appointments:

• 1995 - 1999
  • Assistant Professor; Burn, Trauma, Surgical Critical Care Section, Division of General Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO
• 1995 - present
  • Attending Physician; Barnes-Jewish Hospital, St. Louis, MO
• 1996-present
  • Director, Cellular Injury and Adaptation Laboratory (www.cia.wustl.edu) Washington University School of Medicine, St. Louis, MO
• 2000-2004
  • Associate Professor; Burn, Trauma, Surgical Critical Care Section, Division of General Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO
• 2004
  • Associate Professor (joint appointment); Department of Genetics, Washington University School of Medicine, St. Louis, MO
• 2005-present
  • Professor of Surgery, Washington University School of Medicine, St. Louis, MO
• 2006-present
  • Director, Center for Critical Illness and Health Engineering (www.crihelp.wustl.edu)

Honors and Awards:

• Phi Beta Kappa Society, Vanderbilt University, 1982
• Alpha Omega Alpha Honor Medical Society, The University of Louisville School of Medicine, 1985
• Henry Christian Award/Research Excellence, American Federation of Clinical Research, 1991
• Education Scholarship Award, Society of Critical Care Medicine, 1993
• Fellow of the Year, Multidisciplinary Critical Care Training Program, University of Pittsburgh, 1995
• Research Scholarship Award, American Association for the Surgery of Trauma, 1996
• Founders Post-Fellowship Research Grant, Society of Critical Care Medicine, 1997
• Founders Grant for Training in Critical Care Research, Society of  Critical Care Medicine, 1998
• George H. A. Clowes, Jr. Memorial Research Career Development Award, American College of Surgeons, 2000
• President, Association for Academic Surgery, 2004
• 2nd Annual Critical Care Medicine Distinguished Alumnus, University of Pittsburgh, 2004
• Genome Technology Microarray Innovator, 2005

Memberships and Editorial Boards:

• American College of Surgeons: Fellow
• American Thoracic Society, Critical Care Assembly (2007-present)
• Association for Academic Surgery: Recorder (2000-2002), President (2004)
• European Society of Intensive Care Medicine, International Member, Systemic Inflammation and Sepsis Section (2007-present)
• Journal of Surgical Research Editorial Board (2002-present)
• Shock Society
• Society of Critical Care Medicine: Chair, Research Committee, Surgical Section (2001-2002); Membership Committee (2003); Future of Critical Care Research Committee (2007-2009)
• Society of University Surgeons: Membership Committee (2002-2004)
• Shock Editorial Board (2001-2007)
• Surgical Biology Club II (2000-present)

Funding:

• Current
• National Institutes of Health, Cellular Injury and Adaptation, R01 GM59960-06 (2005-2009)
• National Institutes of Health, Inflammation and the Host Response to Injury "Glue Grant", U54 GM62119, Washington University in St. Louis subcontract,  (2006-2011)
• National Institutes of Health, Physiological Genomics of Critical Illness and Injury, U13 GM73413 (2005-2010)
• National Institutes of Health, Untangling Infection from Inflammation: Pneumonia, R21 GM075023 (2005-2007)
• National Institutes of Health, United States Critical Illness and Injury Trials Group, U13 GM083407 (2008-2011)
• Washington University in St. Louis, Bear Cub Fund (2006-2007)
• Past
• American Association for the Surgery of Trauma Research Scholarship Award, 1996
• Society of Critical Care Medicine Founders Post-Fellowship Research Grant, 1997
• Society of Critical Care Medicine Founders Grant for Training in Critical Care Research, 1998
• American College of Surgeons George H. A. Clowes, Jr. Memorial Research Career Development Award (2000-2005)
• Barnes-Jewish Hospital Foundation Research Award (2005-2007)

• Current
  • Jeff Jones, MD, Post-doctoral research fellow, Division of Infectious Diseases, Department of Internal Medicine, Washington University in St. Louis (2007-present)
  • Jason Werner, MD, Post-doctoral research fellow, Pediatric Critical Care Medicine, Washington University in St. Louis (2006-present)
  • Qing Li, MS, Graduate Student, Mathematics, Washington University in St. Louis (2006-present)
  • Jared Muenzer, MD, Post-doctoral research fellow, Pediatric Emergency Medicine, Washington University in St. Louis (2005-present)
  • Ann Shelton, MSN, Graduate Student, School of Nursing, University of Missouri-St. Louis (UMSL) (2006-present)
• Past
  • Jonathan McDunn, Ph.D., Post-doctoral research fellow (2003-2006), Surgery, Washington University in St. Louis.  Current position:  Instructor, Anesthesiology Research Unit, Department of Anesthesiology, Washington University in St. Louis
  • Ashoka Polpitiya, Ph.D., Post-doctoral research fellow (2004-2006), Surgery, Washington University in St. Louis.  Current position:  Research Fellow, Pacific Northwest National Laboratory, Richland WA
  • Laurence Tam, M.S., Graduate student, Bioengineering Washington University in St. Louis (2003-04).  Current position: Clinical Specialist, Medtronic International, Hong Kong
  • T. Philip Chung, M.D., Post-doctoral research fellow, Surgery Washington University in St. Louis (2000-03).  Current position:  Instructor, Department of Surgery, Washington University in St. Louis
  • Jason M. Laramie, M.S., Graduate student, Computer Science Washington University in St. Louis (2000-03).  Current position: Research Fellow, Bioinformatics and Systems Biology, Boston University
  • Paul A. Berry, B.S., Medical student, WUSM (2000).  Current position: Resident in Plastic Surgery, Texas A&M College of Medicine-Scott and White Memorial Hospital, Temple TX
  • Lakshmi Parvathaneni, M.B.B.S., Medical student (1997-1998).  Current position: Cardiologist, St. Rita's Medical Center, Lima OH
  • Regina Clemens, B.A., Undergraduate student (1997).  Current position: Resident, Department of Pediatrics, University of California--San Francisco
  • Susan L. Gearhart (nee DeMeester), M.D., Post-doctoral research fellow, Surgery (1995-1997).  Current position: Assistant Professor, Department of Surgery, Johns Hopkins Hospital, Baltimore MD

Bibliography:

• 1984-2004
• 2005-present

46. Cobb JP, Warner BW.  Challenges and a New Vision for Academic Surgery. J. Am. Coll. Surg. 200: 605-6, 2005.

47. Dilley WG, Kalyanaraman S., Verma S., Cobb JP, Laramie JM, Lairmore TC. Global Gene Expression in Neuroendocrine Tumors from Patients with the MEN1 Syndrome. Mol. Cancer 4: 9, 2005.

48. Calvano SE, Xiao W, Richards DR, Feliciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF, and and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. A Network-Based Analysis of Systemic Inflammation in Humans. Nature 437:1032-7, 2005.

49. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson C, Hayden DL, Herndon D, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, and and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A., 102:4801-06, 2005.

50. Cobb JP. Uniting the voices of academic surgery: The role of the young voice. J. Surg. Res., 126: 131-6., 2005

51.  Cobb JP.  Functional genomics.  J. Surg. Res. 128:194-8, 2005

52.  Turnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M. DAP12 (KARAP) amplifies inflammation and increases mortality from septic shock. J. Exp. Med. 202: 363-9, 2005.

53.  McDunn JE and Cobb JP. That which does not kill you makes you stronger: A molecular mechanism for preconditioning. Science STKE 2005, pe34, 2005.

54. McDunn JE, Chung TP, Laramie JM, Townsend RR, Cobb JP. Physiological genomics. Surgery 139:133-9, 2006.

55.  Barchet W, Price JD, Cella M, Colonna M, MacMillan SK, Cobb JP, Thompson PA, Murphy KM, Atkinson JP, Kemper C. Complement-induced regulatory T-cells suppress T-cell responses but allow for dendritic cell maturation. Blood 107:1497-504, 2006.

56. Brownstein BH, Logvinenko T, Lederer JA, Cobb JP, Hubbard WJ, Chaudry IH, Remick DG, Baker H, Xiao W, Mannick JM, and the Inflammation and the Host Response to Injury investigators.  Commonality and differences in leukocyte gene expression among three models of inflammation and injury. Physiological Genomics 24:298-309, 2006.

57. Vickle-Chavez SJ, Tung WS, Absi TS, Ennis TL, Mao D, Cobb JP, and Thompson RW. Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms. Journal of Vascular Surgery 43: 1010-20, 2006.

58. Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, De A, Moldawer LL, Bankey P, Richards DR, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Tompkins RG, Davis RW, and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc. Natl. Acad. Sci .U S A. 103:15564-15569, 2006.

59. Chung TP, Laramie JM, Meyer DJ, Downey T, Tam LHY, Ding H, Buchman TG, Karl IE, Stormo GD, Hotchkiss RS, Cobb JP. Class prediction in sepsis: From bedside to bench. J. Am. Coll. Surg. 203: 585-598, 2006.

60. J. E. McDunn, I. R. Turnbull, A. D. Polpitiya, A. Tong, S. K. MacMillan, D. F. Osborne, R. S. Hotchkiss, M. Colonna, and J. P. Cobb. Splenic CD4+ T-cells have a distinct transcriptional response 6 hours after the onset of sepsis. J. Am. Coll. Surg. 203:365-375, 2006.

61. Van Vickle-Chavez SJ, Tung WS, Absi TS, Ennis TL, Mao D, Cobb JP, Thompson RW. Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms. J. Vasc. Surg. 43:1010-20, 2006.

62.  T. H. Wagner, A. M. Drewry, S. K. MacMillan, W. M. Dunne, K. C. Chang, I. E. Karl, R. S. Hotchkiss, and J. P. Cobb. Surviving Sepsis: bcl-2 Overexpression Modulates Splenocyte Transcriptional Responses in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol 292: R1751-9, 2007.

63. McDunn JE, Townsend RR, Cobb JP. The plasma proteome response to polymicrobial intraabdominal sepsis. Proteomics: Clinical Applications 1:373-386, 2007.

64.  J. M. Laramie, T. P. Chung, B. H. Brownstein, G. D. Stormo, and J. P. Cobb. Transcriptional profiles of human epithelial cells in response to heat: computational evidence for novel heat shock proteins. Shock, in press, 2007.

65.  Checchia PA, Schierding W, Polpitiya A, Dixon D, MacMillan S, Muenzer J, Stromberg P, Coopersmith CM, Buchman TG, Cobb JP.  Myocardial transcriptional profiles in a murine model of sepsis: Evidence for the importance of age.  Pediatric Crit. Care Med., in press, 2007.

66.  R. C. Romero-Zaliz, C. Rubio-Escudero, J. P. Cobb, F. Herrera, O. Cordon, and I. Zwir. A multi-objective evolutionary conceptual clustering methodology for gene annotation within structural databases: A case of study on the Gene Ontology database. IEEE Transactions on Evolutionary Computation, in press, 2007.

67. J. A. Lederer, B. H. Brownstein, M. C. Lopez, S. K. MacMillan, A. J. Delisle, M. MacConmara, M. A. Chaudhry, W. Xiao, S. Lekousi, J. P. Cobb, H. V. Baker, J. A. Mannick, I. H. Chaudry, and and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiological Genomics, in press, 2007.

68.  McDunn JE, Husain KD, Polpitiya AD, Burykin A, Ruan J, Li Q, Schierding W, Lin N, Dixon D, Zhang W, Coopersmith CM, Dunne WM, Colonna M, Ghosh B, Cobb JP. Plasticity of the systemic inflammatory response to acute infection during critical illness: Development of the Riboleukogram.  PLoS ONE, in press, 2007.

69.  Rubio-Escudero C, Romero-Zaliz RC, Cordon O, Cobb JP, Zwir I. Identifying gene profiles by reverse problem solving: from grouping gene expressions to combining microarray analysis methods. submitted, 2007.

70.  J. P. Cobb, A. F. Suffredini, and R. L. Danner. Functional Genomics of Critical Illness and Injury: Fourth NIH Symposium. submitted, 2007.

71.  A. K. Shelton, A. F. Fish, J. P. Cobb, J. H. Bachman, R. Jenkins, B. D. Freeman, and V. Battistich. Surrogate Consent for Genomics Research in Intensive Care. submitted, 2007.

72. D. Sornette, V.I. Yukalov, E.P. Yukalova, J.-Y. Henry, D. Schwab, and J.P. Cobb.  Endogenous versus Exogenous Origins of Diseases. submitted, 2007.

last modified December 13, 2007